Inheritance and epidemiology

The disease can be inherited by the autosomal dominant mode, meaning that only one "sick" gene can cause the disease.

In such cases, one of the parents most often has the same illness as the child. The chances of a child getting sick are 1: 2 in each pregnancy.

In other cases, inheritance is autosomically recessive, meaning that both parents are "carriers" of the diseased gene but do not show signs of the disease, and the chances of the child getting the disease are 1: 4. There are more than 10 genes that are known to cause various forms of bullous epidermolysis.

Also, bullous epidermolysis can also develop in the mutation of a gene that occurs at the time of egg or sperm formation in a parent. Both gender and child birth patterns do not affect the EB development potential of a child.

The disease occurs with two or four people per 100,000 inhabitants, all races and ethnic groups, and both sexes are equally affected. Disease is not always visible at birth, so that in the milder forms of illness, the first symptoms appear only when the child begins to crawl, walk and run or in the adolescent age when they start to dealng with physical activity.