Epidermolysis bullosa

Bullous epidermolysis is a group of genetic conditions characterized by strong skin sensitivity, and in some patients and mucous membranes, with the formation of bladder and wound. The skin is sensitive to the slightest pressure, rubbing and touch and very painful wounds such as burns.

There are three basic types or types of diseases, which differ in the depth of separation of the skin layers. Namely, the skin is divided into three layers: epidermis, dermis (skin) and hypoderm (subcutaneous).

The dermis is directly linked to the epidermis over the basal membrane. BE Simplex is formed in the outer part of the skin (epidermis), while Junctional and Dystrophic BE are formed in the basal membrane area.

Over the last decade there has been tremendous progress in understanding these diseases, which are related by new findings on skin texture.

It is characteristic that all illnesses belonging to hereditary bullous epidermolyses are caused by the inherent lack of different proteins in the skin.

These proteins are responsible for connecting different layers and cells in the skin. Because of the change in the amount and / or the quality (structure) of certain proteins, separation of different layers in the skin and mucosa occurs.

Three basic types of Bullous epidermolysis

1. Epidermolysis bullosa simplex
2. Junctional epidermolysis bullosa
3. Dystrophic epidermolysis bullosa